Síntese e modificações estruturais de derivados curcuminóides e avaliação de suas atividades anti-leishmania

Abstract

Curcumin [1,7-bis- (4-hydroxy-3-methoxyphenyl) -1,6-heptadiene-3,5-dione] is extracted from different species of turmeric, and its use is widespread in folk medicine in Asia , India and Africa. From the knowledge of its pharmacological activities, as well as the reaction possibilities offered by its structure, structural changes were made to curcumin, using various types of reactions. Syntheses of differently substituted curcuminoid derivatives were also made in the aromatic ring. The substances obtained were identified by IR spectra (1600 FT), NMR1H (200 MHz), NMR 13C (50.3 MHz) and mass spectrometry (70 ev). In this study, in addition to the reactions carried out, analyzes were carried out through in vitro tests of the potential of antiparasitic activity against the promastigote forms of Leishmania amazonensis. The obtained LD50 values ​​allowed us to hypothesize the relationship between the structure and biological activity exhibited by these products.