Constituintes químicos de Luxemburgia nobilis Eichl

Abstract

This work reports the results from the chemical study of leaves and branches of Luxemburgia nobilis (Ochnacea). The compounds were isolated from the hexane and methanol extracts of the branches and hexane, ethyl acetate and methanol of the leaves by chromatographic process. The structures were established by IR, UV, MS and NMR spectral analyses including 2D NMR experiments of the natural compounds and the derivatives and also by comparision from literature data. The hexane extract of the branches afforded β-sitosterol, stigmasterol, betunilic acid, hexadecanoic acid, tetraeicosanoic acid, hexaeicosanoic acid, linoleic acid, methyl-14-methylpentadecanoate, 13-epimanoyl oxide, atranorin and two new triglicerides 2,3-diexadecanoyl-1-cis,cis-8-11-eicosadienoyl glycerol and 2, 3-diexadecanoyl-1-cis,cis-6-9-octadecadienoyl glycerol. The methanol extract of the branches afforded 3-O-β-D-glucopyranosil-sitosterol, α-amirin, β-amirin, lupeol, 4,2',4'-trihydroxychalcone, 2,5,3',4'-tetrahydroxichalcone, rutin and epicatequin. The hexane extract of the leaves afforded β-sitosterol, hexadecanoic acid, tetraeicosanoic acid, hexaeicosanoic acid. The ethyl acetat extract of the leaves afforded amentoflavone, podocarpusflavone A, friedelin and the new biflavonoid 5,7,4'-trihydroxiflavone-(3'-0-4')-5,7- dihidroxyflavanone. The methanol extract afforded friedelinol, podocarpusflavone A and 5, 7,4'-trihydroxiflavone-(3'-0-4')-5, 7-dihidroxyflavanone. The extracts and 5,7,4'-trihydroxiflavone-(3'-O-4')-5,7-dihidroxyflavanone were not active with Artemia salina test.