Síntese, modelagem molecular e avaliação da atividade inseticida de novos piretróides do tipo éter de oxima

Abstract

This work is part of research program that has as main objective the synthesis of new molecules with potential insecticide activity using abundant natural products as starting materials. We describe herein the synthesis and evaluation of insecticide profile of seven new oxime-ether derivatives, prepared from natural safrole. The final products were obtained as a misture of isomers (E/Z) wich were separeted by conventional chromatograpic methods and were caracterized by usual techniques (NMR1H, NMR 13C, IR, MS). Some evaluated derivatives showed activity against Musca domestica and could be seen as promising prototypes for the development of new insecticides. The utilization of molecular modelling methods allowed us to obtain the conformational profile for our compounds. These results provided a better racionalization of the insecticide activity of these compouds and suggest that the more active compouds could act by two diferent mechanisms: as pyrethroids and/or neonicotinoids.