Avaliação Farmacológica do Extrato Etanólico da Raiz de Memora nodosa (Silva Manso) Miers no Sistema Nervoso Central

Abstract

Memora nodosa (Silva Manso) Miers, is a species of the Bignoniaceae family, popularly known as yellow Caroba, field carobinha, bambuzinho, or being found in the Cerrado biome of Goiás. Reports indicate the use of popular roots in the form of tea to abdominal pain and in bath for scabies. Research with the ethanolic extract of the leaves and roots, in rats and mice suggest that the plant is not potentially toxic and has also antinociceptive activity involving central mechanisms similar to opioids and anti-inflammatory activity that may involve blocking the synthesis or antagonism of different mediators, such as eicosanóides. The objective of this study was to evaluate the effects of the ethanol extract of M.nodosa root (EERMN) in Central Nervous System. In this study, we used swiss mice, and the EERMN at doses of 500, 1000 and 2000 mg/kg, by oral administration, evaluated in Open-Field test (CA), Rota-rod test(RG), Barbiturates Induced Sleep (SIB), Elevated Plus-maze test (LCE) and forced swimming test (Behavioral despair) (NF). Treatment with EERMN was not able to change parameters evaluated in the testing of CA, RG, LCE and NF, reducing, however the latency for inducing sleep and increasing sleep time in the SIB. These results suggest the absence of action anxiolytic, antidepressive or exploratory activity after acute treatment and a hypnosedative action of EERMN, not discarding possible pharmacokinetic interactions with the sleep-inducing agent.