Hidrogéis de carboximetil celulose sódica carregados com óleos bioativos e ureia para o tratamento de feridas

Abstract

The work presents the synthesis, characterization and the study on sodium carboxymethyl cellulose (Na-CMC) hydrogels for the delivery of bioactive oils and urea moisturizer, aiming to obtain healing films for wound care, such as pressure ulcers. The hydrogels were obtained by the casting method with physical crosslinking with citric acid to improve the materials mechanical strength. The obtained films were submitted to immersion in different oils (Copaifera langsdorffii oil, Melaleuca armillaris oil and Melaleuca alternifolia oil) and in 2% urea moisturizer, in which it was evaluated the oils release to the saline solution. It was possible to verify that there was an increase in water resistance due to citric acid action. The oils, urea moisturizer and the films after the absorption period were submitted to FTIR analysis, as well as the films before and after the swelling test to analyze the physical and/or chemical interactions between the materials. it was possible to identify the interaction of citric acid with the materials. The TGA was used to thermal evaluation, where thermal decays and the loss of mass were evaluated. gas chromatography coupled with mass spectrometry (GC-MS) was a test used to identify the chemical constituents present in the bioactive oils. The tensile tests evaluated the strength of the films.the addition of oils/urea granted greater flexibility in some films. Antimicrobial tests were performed with the oils and the films by the Mueller-Hinton agar diffusion method, using the bacteria Staphylococcus aureus, the oils exhibited inhibition halos considerably high and the films showed antimicrobial activity against S. aureus.